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KMID : 1039120200090020159
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Clinical and Experimental Vaccine Research
2020 Volume.9 No. 2 p.159 ~ p.163
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Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
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Grippo Lucia Daniela
Reidel Ivana Gabriela
Garcia Maria Ines
Streu Alexis
Muller Diana Maria
Veaute Carolina Melania
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Abstract
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The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
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KEYWORD
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Vaccines, DNA, Adjuvants, Immunostimulants, gemini lipopeptides
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